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Antimicrobial Agents and Chemotherapy, November 1998, p. 3012-3013, Vol. 42, No. 11
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

In Vitro Activity of a New Polyene, SPA-S-843, against Yeasts

C. Rimaroli* and T. Bruzzese

Research Laboratories, Società Prodotti Antibiotici SpA, 20143 Milan, Italy

Received 7 May 1998/Returned for modification 8 June 1998/Accepted 3 September 1998

The in vitro activity of a new water-soluble polyene, SPA-S-843, was evaluated against 116 strains of Candida, Cryptococcus, and Saccharomyces spp. and compared with that of amphotericin B. SPA-S-843 demonstrated better inhibitory activity against all of the yeasts examined and better fungicidal activity against Candida albicans, Candida glabrata, Candida krusei, and Candida tropicalis than did amphotericin B.

* Corresponding author. Mailing address: Società Prodotti Antibiotici, Via Biella 8, 20143 Milan, Italy. Phone: (02) 891391. Fax: (02) 8132983. E-mail: dm{at}apm.it.

Antimicrobial Agents and Chemotherapy, November 1998, p. 3012-3013, Vol. 42, No. 11
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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