This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Manavathu, E. K.
Right arrow Articles by Chandrasekar, P. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Manavathu, E. K.
Right arrow Articles by Chandrasekar, P. H.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, November 1998, p. 3018-3021, Vol. 42, No. 11
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Organism-Dependent Fungicidal Activities of Azoles

Elias K. Manavathu,* Jessica L. Cutright, and Pranatharthi H. Chandrasekar

Division of Infectious Diseases, Department of Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201

Received 8 December 1997/Returned for modification 10 March 1998/Accepted 13 August 1998

We investigated the antifungal activities of itraconazole and voriconazole on Aspergillus species by time kill studies, and the results were compared with those obtained for Candida species. Exposure of Aspergillus fumigatus conidia to varying concentrations (1.25 to 10 µg/ml) of itraconazole and voriconazole resulted in cellular death; the cytocidal effect was time and concentration dependent. In contrast, no killing of Candida albicans occurred in the presence of itraconazole and voriconazole at concentrations as high as 10 µg/ml, although candidal growth was inhibited compared to the drug-free control. Amphotericin B (1.25 to 10 µg/ml), on the other hand, killed both A. fumigatus and C. albicans. Similar results were obtained for non-A. fumigatus aspergilli and non-C. albicans Candida species. These observations indicate that both itraconazole and voriconazole are cytocidal agents for Aspergillus species but not for Candida species, suggesting that azoles possess organism-dependent fungicidal activities.

* Corresponding author. Mailing address: Department of Medicine, Wayne State University, 427 Lande Building, 550 E. Canfield, Detroit, MI 48201. Phone: (313) 577-1931. Fax: (313) 993-0302. E-mail: aa1388{at}wayne.edu.

Antimicrobial Agents and Chemotherapy, November 1998, p. 3018-3021, Vol. 42, No. 11
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Meletiadis, J., Antachopoulos, C., Stergiopoulou, T., Pournaras, S., Roilides, E., Walsh, T. J. (2007). Differential Fungicidal Activities of Amphotericin B and Voriconazole against Aspergillus Species Determined by Microbroth Methodology. Antimicrob. Agents Chemother. 51: 3329-3337 [Abstract] [Full Text]  
  • Li, Y., Nguyen, M. H., Derendorf, H., Cheng, S., Clancy, C. J. (2007). Measurement of Voriconazole Activity against Candida albicans, C. glabrata, and C. parapsilosis Isolates Using Time-Kill Methods Validated by High-Performance Liquid Chromatography. Antimicrob. Agents Chemother. 51: 2985-2987 [Abstract] [Full Text]  
  • Groll, A. H., Mickiene, D., Petraitis, V., Petraitiene, R., Kelaher, A., Sarafandi, A., Wuerthwein, G., Bacher, J., Walsh, T. J. (2005). Compartmental pharmacokinetics and tissue distribution of the antifungal triazole ravuconazole following intravenous administration of its di-lysine phosphoester prodrug (BMS-379224) in rabbits. J Antimicrob Chemother 56: 899-907 [Abstract] [Full Text]  
  • Krishnan, S., Manavathu, E. K., Chandrasekar, P. H. (2005). A comparative study of fungicidal activities of voriconazole and amphotericin B against hyphae of Aspergillus fumigatus. J Antimicrob Chemother 55: 914-920 [Abstract] [Full Text]  
  • Lewis, R. E., Wiederhold, N. P., Klepser, M. E. (2005). In Vitro Pharmacodynamics of Amphotericin B, Itraconazole, and Voriconazole against Aspergillus, Fusarium, and Scedosporium spp.. Antimicrob. Agents Chemother. 49: 945-951 [Abstract] [Full Text]  
  • Di Bonaventura, G., Spedicato, I., Picciani, C., D'Antonio, D., Piccolomini, R. (2004). In Vitro Pharmacodynamic Characteristics of Amphotericin B, Caspofungin, Fluconazole, and Voriconazole against Bloodstream Isolates of Infrequent Candida Species from Patients with Hematologic Malignancies. Antimicrob. Agents Chemother. 48: 4453-4456 [Abstract] [Full Text]  
  • Chryssanthou, E., Sjolin, J. (2004). Post-antifungal effect of amphotericin B and voriconazole against Aspergillus fumigatus analysed by an automated method based on fungal CO2 production: dependence on exposure time and drug concentration. J Antimicrob Chemother 54: 940-943 [Abstract] [Full Text]  
  • Conte, J. E. Jr., Golden, J. A., Kipps, J., McIver, M., Zurlinden, E. (2004). Intrapulmonary Pharmacokinetics and Pharmacodynamics of Itraconazole and 14-Hydroxyitraconazole at Steady State. Antimicrob. Agents Chemother. 48: 3823-3827 [Abstract] [Full Text]  
  • Manavathu, E. K., Ramesh, M. S., Baskaran, I., Ganesan, L. T., Chandrasekar, P. H. (2004). A comparative study of the post-antifungal effect (PAFE) of amphotericin B, triazoles and echinocandins on Aspergillus fumigatus and Candida albicans. J Antimicrob Chemother 53: 386-389 [Abstract] [Full Text]  
  • Glasmacher, A., Prentice, A., Gorschluter, M., Engelhart, S., Hahn, C., Djulbegovic, B., Schmidt-Wolf, I. G.H. (2003). Itraconazole Prevents Invasive Fungal Infections in Neutropenic Patients Treated for Hematologic Malignancies: Evidence From a Meta-Analysis of 3,597 Patients. JCO 21: 4615-4626 [Abstract] [Full Text]  
  • Pearson, M. M, Rogers, P D., Cleary, J. D, Chapman, S. W (2003). Voriconazole: A New Triazole Antifungal Agent. The Annals of Pharmacotherapy 37: 420-432 [Abstract] [Full Text]  
  • Pfaller, M. A., Diekema, D. J., Messer, S. A., Boyken, L., Hollis, R. J., Jones, R. N. (2003). In Vitro Activities of Voriconazole, Posaconazole, and Four Licensed Systemic Antifungal Agents against Candida Species Infrequently Isolated from Blood. J. Clin. Microbiol. 41: 78-83 [Abstract] [Full Text]  
  • Bowman, J. C., Hicks, P. S., Kurtz, M. B., Rosen, H., Schmatz, D. M., Liberator, P. A., Douglas, C. M. (2002). The Antifungal Echinocandin Caspofungin Acetate Kills Growing Cells of Aspergillus fumigatus In Vitro. Antimicrob. Agents Chemother. 46: 3001-3012 [Abstract] [Full Text]  
  • Becker, M. J., de Marie, S., Fens, M. H. A. M., Hop, W. C. J., Verbrugh, H. A., Bakker-Woudenberg, I. A. J. M. (2002). Enhanced antifungal efficacy in experimental invasive pulmonary aspergillosis by combination of AmBisome with Fungizone as assessed by several parameters of antifungal response. J Antimicrob Chemother 49: 813-820 [Abstract] [Full Text]  
  • Bowman, J. C., Abruzzo, G. K., Anderson, J. W., Flattery, A. M., Gill, C. J., Pikounis, V. B., Schmatz, D. M., Liberator, P. A., Douglas, C. M. (2001). Quantitative PCR Assay To Measure Aspergillus fumigatus Burden in a Murine Model of Disseminated Aspergillosis: Demonstration of Efficacy of Caspofungin Acetate. Antimicrob. Agents Chemother. 45: 3474-3481 [Abstract] [Full Text]  
  • Boogaerts, M., Winston, D. J., Bow, E. J., Garber, G., Reboli, A. C., Schwarer, A. P., Novitzky, N., Boehme, A., Chwetzoff, E., De Beule, K., the Itraconazole Neutropenia Study Group*, (2001). Intravenous and Oral Itraconazole versus Intravenous Amphotericin B Deoxycholate as Empirical Antifungal Therapy for Persistent Fever in Neutropenic Patients with Cancer Who Are Receiving Broad-Spectrum Antibacterial Therapy: A Randomized, Controlled Trial. ANN INTERN MED 135: 412-422 [Abstract] [Full Text]  
  • Osherov, N., Kontoyiannis, D. P., Romans, A., May, G. S. (2001). Resistance to itraconazole in Aspergillus nidulans and Aspergillus fumigatus is conferred by extra copies of the A. nidulans P-450 14{{alpha}}-demethylase gene, pdmA. J Antimicrob Chemother 48: 75-81 [Abstract] [Full Text]  
  • Manavathu, E. K., Cutright, J. L., Loebenberg, D., Chandrasekar, P. H. (2000). A comparative study of the in vitro susceptibilities of clinical and laboratory-selected resistant isolates of Aspergillus spp. to amphotericin B, itraconazole, voriconazole and posaconazole (SCH 56592). J Antimicrob Chemother 46: 229-234 [Abstract] [Full Text]  
  • Chandrasekar, P. H., Cutright, J., Manavathu, E. (2000). Efficacy of voriconazole against invasive pulmonary aspergillosis in a guinea-pig model. J Antimicrob Chemother 45: 673-676 [Abstract] [Full Text]  
  • Manavathu, E. K., Cutright, J., Chandrasekar, P. H. (1999). Comparative Study of Susceptibilities of Germinated and Ungerminated Conidia of Aspergillus fumigatus to Various Antifungal Agents. J. Clin. Microbiol. 37: 858-861 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»