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Antimicrobial Agents and Chemotherapy, November 1998, p. 3035-3037, Vol. 42, No. 11
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Bactericidal Activities of the Pyrrole Derivative BM212 against Multidrug-Resistant and Intramacrophagic Mycobacterium tuberculosis Strains

Delia Deidda,1,* Giorgio Lampis,1 Rossella Fioravanti,2 Mariangela Biava,2 Giulio Cesare Porretta,2 Stefania Zanetti,3 and Raffaello Pompei1

Dipartimento di Scienze Mediche, Cattedra di Microbiologia, Università di Cagliari, Cagliari,1 Dipartimento di Studi di Chimica TSBA Università "la Sapienza" di Roma, Rome,2 and Istituto di Microbiologia, Università di Sassari, Sassari,3 Italy

Received 21 January 1998/Returned for modification 22 July 1998/Accepted 24 August 1998

The pyrrole derivative BM212 [1,5-diaryl-2-methyl-3-(4-methylpiperazin-1-yl)methyl-pyrrole] was shown to possess strong inhibitory activity against both Mycobacterium tuberculosis and some nontuberculosis mycobacteria. BM212 was inhibitory to drug-resistant mycobacteria and also exerted bactericidal activity against intracellular bacilli residing in the U937 human histiocytic lymphoma cell line.

* Corresponding author. Mailing address: Cattedra di Microbiologia Applicata, Universita' di Cagliari, via Porcell 4, 09124 Cagliari, Italy. Phone: (070) 6758483. Fax: (070) 6758482. E-mail: rpompei{at}unica.it.

Antimicrobial Agents and Chemotherapy, November 1998, p. 3035-3037, Vol. 42, No. 11
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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Copyright © 1998 by the American Society for Microbiology. All rights reserved.