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Antimicrobial Agents and Chemotherapy, December 1998, p. 3276-3278, Vol. 42, No. 12
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Rapid Emergence of High-Level Resistance to Quinolones in Campylobacter jejuni Associated with Mutational Changes in gyrA and parC

Amera Gibreel,1 Eva Sjögren,2 Bertil Kaijser,2 Bengt Wretlind,3 and Ola Sköld1,*

Division of Microbiology, Department of Pharmaceutical Biosciences, Biomedical Center, Uppsala University, Uppsala,1 Department of Clinical Bacteriology, Göteborg University, Göteborg,2 and Bacteriological Laboratory, Karolinska Hospital, Stockholm,3 Sweden

Received 15 June 1998/Returned for modification 13 July 1998/Accepted 9 September 1998

Quinolone resistance in clinical isolates of Campylobacter jejuni in Sweden increased more than 20-fold at the beginning of the 1990s. Resistance to 125 µg of ciprofloxacin per ml in clinical isolates was associated with chromosomal mutations in C. jejuni leading to a Thr-86-Ile substitution in the gyrA product and a Arg-139-Gln substitution in the parC product.

* Corresponding author. Mailing address: Division of Microbiology, Department of Pharmaceutical Biosciences, P.O. Box 581, Biomedical Center, Uppsala University, S-751 23 Uppsala, Sweden. Phone: 46-18-4714500. Fax: 46-18-502790. E-mail: ola.skold{at}farmbio.uu.se.

Antimicrobial Agents and Chemotherapy, December 1998, p. 3276-3278, Vol. 42, No. 12
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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