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Antimicrobial Agents and Chemotherapy, December 1998, p. 3282-3284, Vol. 42, No. 12
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Joint Tolerance to beta -Lactam and Fluoroquinolone Antibiotics in Escherichia coli Results from Overexpression of hipA

Timothy J. Falla and Ian Chopra*

Department of Microbiology and Antimicrobial Research Centre, University of Leeds, Leeds LS2 9JT, United Kingdom

Received 5 March 1998/Returned for modification 27 April 1998/Accepted 17 September 1998

The basis of joint tolerance to beta -lactam and fluoroquinolone antibiotics in Escherichia coli mediated by hipA was examined. An antibiotic tolerance phenotype was produced by overexpression of hipA under conditions that did not affect the growth rate of the organism. Overexpressing hipA probably decreases the period in which bacteria are susceptible to the antibiotics by temporarily affecting some aspect of chromosome replication or cell division.

* Corresponding author. Mailing address: Department of Microbiology and Antimicrobial Research Centre, University of Leeds, Leeds LS2 9JT, United Kingdom. Phone: 44 113 233 5604. Fax: 44 113 233 5638. E-mail: micic{at}leeds.ac.uk.

Antimicrobial Agents and Chemotherapy, December 1998, p. 3282-3284, Vol. 42, No. 12
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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