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Antimicrobial Agents and Chemotherapy, December 1998, p. 3315-3316, Vol. 42, No. 12
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

In Vitro Activities of Several Diaminomethylpyridopyrimidines against Mycobacterium avium Complex

Carolyn M. Shoen,1 Olga Choromanska,1 Robert C. Reynolds,2 James R. Piper,2 Cheryl A. Johnson,2 and Michael H. Cynamon1,*

Department of Medicine, Veterans Affairs Medical Center, Syracuse, New York,1 and Southern Research Institute, Birmingham, Alabama2

Received 29 May 1998/Returned for modification 21 July 1998/Accepted 11 September 1998

Three recently synthesized dihydrofolate reductase (DHFR) inhibitors designated SoRI 8890, 8895, and 8897 were evaluated for their in vitro activities against 25 isolates of Mycobacterium avium complex. The MICs at which 50 and 90% of isolates were inhibited were 1 and 2, 4 and 8, and 4 and 8 µg/ml for SoRI 8890, 8895, and 8897, respectively. Although the addition of dapsone at 0.5 µg/ml did not significantly enhance the in vitro activities of these compounds, their activities alone were comparable to, if not better than, results seen with other DHFR inhibitors, such as pyrimethamine or WR99210.

* Corresponding author. Mailing address: VAMC, 800 Irving Ave., Syracuse, NY 13210. Phone: (315) 476-7461, ext. 3324. Fax: (315) 476-5348. E-mail: Cynamon.Michael{at}syracuse.VA.Gov.

Antimicrobial Agents and Chemotherapy, December 1998, p. 3315-3316, Vol. 42, No. 12
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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Copyright © 1998 by the American Society for Microbiology. All rights reserved.