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Antimicrobial Agents and Chemotherapy, December 1998, p. 3320-3324, Vol. 42, No. 12
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

In Vitro Activities of Membrane-Active Peptides against Gram-Positive and Gram-Negative Aerobic Bacteria

A. Giacometti,* O. Cirioni, G. Greganti, M. Quarta, and G. Scalise

Institute of Infectious Diseases and Public Health, University of Ancona, Ancona, Italy

Received 9 April 1998/Returned for modification 26 July 1998/Accepted 4 October 1998

Four peptides, cecropin P1, magainin II, indolicidin, and ranalexin, were evaluated against 202 clinical isolates of gram-positive and gram-negative aerobic bacteria by a microbroth dilution method. The gram-negative isolates were more susceptible to cecropin P1. Ranalexin was the most active compound against the gram-positive strains. The bactericidal activity of each peptide was equivalent to, or 1 dilution above, the MIC. In conclusion, the four peptides exhibited different in vitro activities and rapid time-dependent killing.

* Corresponding author. Mailing address: Clinica delle Malattie Infettive, c/o Azienda Ospedaliera Umberto I, Piazza Cappelli, 1, 60121 Ancona, Italy. Phone: 39 71 5963467. Fax: 39 71 5963468. E-mail: cmalinf{at}popcsi.unian.it.

Antimicrobial Agents and Chemotherapy, December 1998, p. 3320-3324, Vol. 42, No. 12
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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