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Antimicrobial Agents and Chemotherapy, February 1998, p. 257-262, Vol. 42, No. 2
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

A Novel Erythromycin Resistance Methylase Gene (ermTR) in Streptococcus pyogenes

Helena Seppälä,1,* Mikael Skurnik,2 Hanna Soini,3 Marilyn C. Roberts,4 and Pentti Huovinen1

Antimicrobial Research Laboratory1 and the Mycobacterial Reference Laboratory,3 National Public Health Institute, 20520 Turku, Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, 20521 Turku,2 Finland, and Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington 981954

Received 14 May 1997/Returned for modification 7 August 1997/Accepted 11 November 1997

Erythromycin resistance among streptococci is commonly due to target site modification by an rRNA-methylating enzyme, which results in coresistance to macrolide, lincosamide, and streptogramin B antibiotics (MLSB resistance). Genes belonging to the ermAM (ermB) gene class are the only erythromycin resistance methylase (erm) genes in Streptococcus pyogenes with MLSB resistance that have been sequenced so far. We identified a novel erm gene, designated ermTR, from an erythromycin-resistant clinical strain of S. pyogenes (strain A200) with an inducible type of MLSB resistance. The nucleotide sequence of ermTR is 82.5% identical to ermA, previously found, for example, in Staphylococcus aureus and coagulase-negative staphylococci. Our finding provides the first sequence of an erm gene other than ermAM that mediates MLSB resistance in S. pyogenes.

* Corresponding author. Mailing address: Antimicrobial Research Laboratory, National Public Health Institute, Kiinamyllynkatu 13, 20520 Turku, Finland. Phone: 358-2-2519255. Fax: 358-2-2519254. E-mail: helena.seppala{at}utu.fi.

Antimicrobial Agents and Chemotherapy, February 1998, p. 257-262, Vol. 42, No. 2
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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