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Antimicrobial Agents and Chemotherapy, February 1998, p. 425-427, Vol. 42, No. 2
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Concentrations of Pefloxacin in Plasma and Tissue after Administration as Surgical Prophylaxis

Bernadette Jacoberger,1 Genevieve Ubeaud,2 Guy Freys,3 Thierry Pottecher,3 Louis Jung,2 and Jean Claude Koffel1,2,*

Department of Pharmacy1 and Department of Anesthesia and Intensive Care,3 University Hospital Hautepierre, 67098 Strasbourg Cedex, and University of Pharmacy, 67400 Illkirch Graffenstaden,2 France

Received 15 January 1997/Returned for modification 18 July 1997/Accepted 15 November 1997

Plasma and epiploic-fat drug concentrations determined by high-performance liquid chromatography and fat penetration of pefloxacin and its metabolite (norfloxacin) given for antimicrobial prophylaxis were studied in patients scheduled for colorectal surgery. Concentrations of pefloxacin in plasma decreased about 40% from the beginning of the operation to closure of the peritoneum, and corresponding levels in epiploic fat stayed stable. The plasma and tissue norfloxacin concentrations were very low. Concentrations of pefloxacin in tissue were greater than MIC at which 90% of isolates are inhibited for sensitive bacteria (members of the family Enterobacteriaceae). The penetration of pefloxacin into epiploic fat was about 32%.

* Corresponding author. Mailing address: Department of Pharmacy, University Hospital Hautepierre, 1, ave. Moliere, 67098 Strasbourg Cedex, France. Phone: (33) 3 88 12 78 03. Fax: (33) 3 88 12 78 04. E-mail: jckoffel{at}pharma.u-strosbg.fr.

Antimicrobial Agents and Chemotherapy, February 1998, p. 425-427, Vol. 42, No. 2
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.




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