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Antimicrobial Agents and Chemotherapy, February 1998, p. 428-430, Vol. 42, No. 2
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Pharmacokinetics and Inflammatory Fluid Penetration of Clinafloxacin

R. Wise,* S. Jones, I. Das, and J. M. Andrews

Department of Microbiology, City Hospital NHS Trust, Birmingham, United Kingdom

Received 24 March 1997/Returned for modification 18 September 1997/Accepted 15 November 1997

A single 200-mg dose of clinafloxacin was given orally to each of nine healthy male volunteers, and the concentrations of the drug were measured in plasma, cantharidin-induced inflammatory fluid, and urine over the following 24 h (48 h in the case of urine). The mean maximum concentration in plasma was 1.34 µg/ml at a mean time of 1.8 h postdose. The mean maximum concentration in the inflammatory fluid was 1.3 µg/ml at 3.8 h postdose. The mean elimination half-life of clinafloxacin in plasma was 5.65 h. The overall penetration into the inflammatory fluid was 93.1%, as assessed by determining the ratio of area under the concentration-time curves. Recovery of clinafloxacin in urine was 58.8% by 24 h and 71.8% by 48 h postdose.

* Corresponding author. Mailing address: Department of Microbiology, City Hospital NHS Trust, Dudley Rd., Birmingham B18 7QH, United Kingdom. Phone: 121-554-3801, ext. 4255. Fax: 121-551-7763. E-mail: r.wise{at}bham.ac.uk.

Antimicrobial Agents and Chemotherapy, February 1998, p. 428-430, Vol. 42, No. 2
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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