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Antimicrobial Agents and Chemotherapy, February 1998, p. 440-443, Vol. 42, No. 2
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Antimicrobial Resistance in Shigella flexneri and Shigella sonnei in Hong Kong, 1986 to 1995

Yiu-wai Chu,1 Elizabeth T. S. Houang,1 Donald J. Lyon,1,* Julia M. Ling,1 Tak-keung Ng,2 and Augustine F. B. Cheng1

Department of Microbiology, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, New Territories,1 and Department of Pathology, Princess Margaret Hospital, Kowloon,2 Hong Kong

Received 30 May 1997/Returned for modification 7 August 1997/Accepted 14 November 1997

Three hundred and thirty-three Shigella isolates obtained in 1986 to 1995 were tested for their susceptibilities to 19 antimicrobial agents. Nalidixic acid resistance had emerged in 59.6% of Shigella flexneri isolates during 1994 to 1995, with all tested resistant isolates having the mutation in gyrA encoding the Ser-83 alteration. Multiresistance (resistance to four or more agents) was more common in S. flexneri than in Shigella sonnei.

* Corresponding author. Mailing address: Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Ngan Shing St., Shatin, New Territories, Hong Kong. Phone: (852) 2632 3339. Fax: (852) 2647 3227. E-mail: b176721{at}cuhk.edu.hk.

Antimicrobial Agents and Chemotherapy, February 1998, p. 440-443, Vol. 42, No. 2
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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