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Antimicrobial Agents and Chemotherapy, February 1998, p. 453-455, Vol. 42, No. 2
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Effects of Aluminum Hydroxide and Famotidine on Bioavailability of Tosufloxacin in Healthy Volunteers

Rumiko Minami, Chizuko Nakamura, Nobuo Inotsume,dagger and Masahiro Nakano*

Department of Pharmaceutical Services, Kumamoto University Hospital, 1-1-1 Honjo, Kumamoto 860, Japan

Received 29 July 1996/Returned for modification 15 June 1997/Accepted 1 November 1997

This study was designed to determine the influence of aluminum hydroxide and famotidine on the bioavailability of tosufloxacin. Coadministration of aluminum hydroxide reduced the bioavailability of tosufloxacin by 31.6% (P < 0.05). Famotidine did not alter tosufloxacin absorption. To avoid potential treatment failures, the concurrent use of tosufloxacin and aluminum hydroxide should be avoided altogether.

* Corresponding author. Mailing address: Department of Pharmaceutical Services, Kumamoto University Hospital, 1-1-1 Honjo, Kumamoto 860-0811, Japan. Phone: (81)96-373-5820. Fax: (81)96-373-5906. E-mail: nakano{at}kaiju.medic.kumamoto-u.ac.jp.

dagger Present address: Department of Hospital Pharmacy, Tokyo Medical and Dental University School of Medicine, Tokyo 113, Japan.

Antimicrobial Agents and Chemotherapy, February 1998, p. 453-455, Vol. 42, No. 2
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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