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Antimicrobial Agents and Chemotherapy, February 1998, p. 459-461, Vol. 42, No. 2
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Rationale for and Efficacy of Prolonged-Interval Treatment Using Liposome-Encapsulated Amikacin in Experimental Mycobacterium avium Infection

S. Leitzke,1,* W. Bucke,2 K. Borner,3 R. Müller,2 H. Hahn,1 and S. Ehlers4

Department of Infectious Diseases, Benjamin Franklin University Clinic, Free University of Berlin, D-12203 Berlin,1 Department of Pharmaceutical Technology, Free University of Berlin, D-12169 Berlin,2 Department of Clinical Chemistry and Clinical Biochemistry, Benjamin Franklin University Clinic, Free University of Berlin, D-12200 Berlin,3 and Division of Molecular Infection Biology, Research Center Borstel, D-23845 Borstel,4 Germany

Received 11 June 1997/Returned for modification 18 August 1997/Accepted 26 September 1997

The potential of liposome-encapsulated antibiotics for prolonging drug application intervals was investigated by using a murine model of chronic lethal Mycobacterium avium infection. Liposomal encapsulation of amikacin, but not of ciprofloxacin, resulted in high and sustained drug levels in infected tissues, exceeding the minimal inhibitory concentration for M. avium for at least 28 days. As a consequence, once-weekly and even once-monthly treatments with liposomal amikacin significantly reduced bacterial replication in infected tissues and extended the survival time of infected mice.

* Corresponding author. Mailing address: Department of Infectious Diseases, Benjamin Franklin University Clinic, Free University of Berlin, Hindenburgdamm 27, D-12203 Berlin, Germany. Phone: 49-30-8445-3654. Fax: 49-30-8445-3830. E-mail: Leitzke{at}zedat.fu-berlin.de.

Antimicrobial Agents and Chemotherapy, February 1998, p. 459-461, Vol. 42, No. 2
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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