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Antimicrobial Agents and Chemotherapy, February 1998, p. 464-467, Vol. 42, No. 2
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Characterization of FOX-3, an AmpC-Type Plasmid-Mediated beta -Lactamase from an Italian Isolate of Klebsiella oxytoca

Anna Marchese,1 Guillaume Arlet,2,* Gian Carlo Schito,1 Philippe H. Lagrange,2 and Alain Philippon2

Istituto Di Microbiologia, 16132 Genoa, Italy,1 and Service de Microbiologie, Hôpital Saint-Louis, 75475 Paris, France2

Received 10 April 1997/Returned for modification 12 August 1997/Accepted 24 November 1997

Klebsiella oxytoca 1731, which showed a wide spectrum of resistance to beta -lactams, including cefoxitin, was isolated in 1994 from a patient in Genoa, Italy. This strain contained a plasmid-mediated AmpC beta -lactamase with a pI of 7.25. Sequencing of the corresponding DNA of K. oxytoca 1731 revealed 96 and 97% identities of the deduced amino acid sequence with FOX-1 and FOX-2, respectively.

* Corresponding author. Mailing address: Hôpital Saint-Louis, Laboratoire de Microbiologie, 1 ave. Claude Vellefaux, 75475 Paris Cedex 10, France. Phone: 33 (0)1 42 49 94 87. Fax: 33 (0)1 42 49 94 86. E-mail: a.philippon{at}chu-stlouis.fr.

Antimicrobial Agents and Chemotherapy, February 1998, p. 464-467, Vol. 42, No. 2
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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