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Antimicrobial Agents and Chemotherapy, February 1998, p. 473-474, Vol. 42, No. 2
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Effect of Cholera Toxin on Intestinal Elimination of Ciprofloxacin in Rabbits

Albert Musafija,1 Asher Barzilai,1 Jacob Ramon,2 and Ethan Rubinstein1,*

Infectious Diseases Unit1 and Department of Urology,2 Chaim Sheba Medical Center, Tel Aviv University School of Medicine, Tel Hashomer, Israel

Received 17 March 1997/Returned for modification 24 July 1997/Accepted 15 November 1997

The transepithelial intestinal elimination of ciprofloxacin (CPX) was studied in cholera toxin (CT)-challenged and control intestinal loops in the rabbit. CPX concentrations were similar in CT-challenged and control jejunal and ileal loops, while cecal elimination was negligible. The quantities of eliminated CPX per square centimeter of bowel wall were significantly higher in the small intestine CT-challenged loops. The mechanism of elimination of CPX in the small intestine is therefore mainly passive diffusion.

* Corresponding author. Mailing address: Infectious Diseases Unit, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel. Phone: 972-3-5303500. Fax: 972-3-5347081. E-mail: unit{at}netvision.net.il.

Antimicrobial Agents and Chemotherapy, February 1998, p. 473-474, Vol. 42, No. 2
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Musafija, A., Shtelman, Y., Ramon, J., Volk, M., Segev, S., Rubinstein, E. (2001). The effect of Escherichia coli heat-stable toxin on the trans-epithelial intestinal elimination of ciprofloxacin in the rabbit. J Antimicrob Chemother 47: 697-699 [Abstract] [Full Text]  
  • Musafija, A., Ramon, J., Shtelman, Y., Yoseph, G., Rubinovitz, B., Segev, S., Rubinstein, E. (2000). Trans-epithelial intestinal elimination of moxifloxacin in rabbits. J Antimicrob Chemother 45: 803-805 [Abstract] [Full Text]  


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