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Antimicrobial Agents and Chemotherapy, March 1998, p. 601-605, Vol. 42, No. 3
Division of Geographic Medicine, Department
of Medicine, Case Western Reserve University and
University Hospitals, Cleveland, Ohio 441061;
African Medical and Research
Foundation,2
Nairobi
University School of Veterinary Medicine,3
and
Jomo Kenyatta University of Agriculture and
Technology,4 Nairobi, Kenya; and
Centers for Disease Control and Prevention, Atlanta, Georgia
303295
Received 9 September 1997/Returned for modification 21 October
1997/Accepted 19 December 1997
Few chemotherapeutic agents are available for the medical
management of hydatid disease caused by the parasite Echinococcus granulosus. In order to test the potential of oxfendazole for the
treatment of infection with this parasite, nine infected goats and four
sheep were given oxfendazole twice weekly at a dose of 30 mg/kg of body
weight for 4 weeks and monitored by ultrasound for an additional 4 weeks. Efficacy was finally evaluated by postmortem examination,
including determination of protoscolex viability and cyst wall
histology. In treated animals, protoscolices were dead or absent in
97% of cysts from oxfendazole-treated animals compared to 28% of
cysts from untreated control animals. On postmortem examination, 53%
of cysts from treated animals were found to be grossly degenerate. A
sample of those cysts that appeared potentially viable all demonstrated
evidence of severe damage to the cyst wall. By light microscopy, cysts
showed severe disorganization of the adventitial layer with invasion of
inflammatory cells and in some cases frank necrosis with no apparent
adventitial layer. The follow-up period for assessment of the drug's
ability to cause complete degeneration and resorption of cysts was
relatively short. This study, however, indicates that oxfendazole is at
least as effective as and is easier to administer than albendazole for the treatment of hydatid disease.
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
Oxfendazole Treatment for Cystic Hydatid Disease in
Naturally Infected Animals
*
Corresponding author. Mailing address: Division of
Geographic Medicine, Case Western Reserve University School of
Medicine, 2109 Adelbert Rd., Cleveland, OH 44106-4983. Phone: (216)
368-4814. Fax: (216) 368-4825. E-mail: reb6{at}po.cwru.edu.
Antimicrobial Agents and Chemotherapy, March 1998, p. 601-605, Vol. 42, No. 3
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
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