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Antimicrobial Agents and Chemotherapy, March 1998, p. 691-694, Vol. 42, No. 3
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Neurotoxicodynamics of the Interaction between Ciprofloxacin and Foscarnet in Mice

Hirotami Matsuo,1 Miwako Ryu,1 Aya Nagata,1 Takahiro Uchida,1 Jun-Ichi Kawakami,2 Koujirou Yamamoto,2 Tatsuji Iga,2 and Yasufumi Sawada1,*

Faculty of Pharmaceutical Sciences, Kyushu University, Higashi-ku, Fukuoka 812-8582,1 and Department of Pharmacy, University of Tokyo Hospital, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-8655,2 Japan

Received 24 February 1997/Returned for modification 18 July 1997/Accepted 22 November 1997

The potential for convulsions induced by the coadministration of ciprofloxacin (CPFX) and foscarnet (PFA) may be due not to a change in the distribution of CPFX to the brain but to a potential CPFX-induced inhibition of gamma -aminobutyric acid (GABA)-GABAA receptor binding in the presence of PFA.

* Corresponding author. Mailing address: Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Phone: 81-92-642-6610. Fax: 81-92-642-6614. E-mail: yasufumi{at}yakuzai.phar.kyushu-u.ac.jp.

Antimicrobial Agents and Chemotherapy, March 1998, p. 691-694, Vol. 42, No. 3
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.




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