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Antimicrobial Agents and Chemotherapy, March 1998, p. 700-702, Vol. 42, No. 3
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Antimicrobial Activity of Novel Furanonaphthoquinone Analogs

Kumiko Nagata,1,* Kei-Ichi Hirai,2 Junko Koyama,3 Yasunao Wada,4 and Toshihide Tamura1

Department of Bacteriology1 and Clinical Laboratory,4 Hyogo College of Medicine, Nishinomiya, Hyogo 663, Department of Anatomy, Kanazawa Medical University, Uchinada, Ishikawa 920-02,2 and Kobe Pharmaceutical University, Motoyamakita-machi, Higashinada-ku, Kobe 658,3 Japan

Received 3 June 1997/Returned for modification 17 July 1997/Accepted 17 December 1997

Analogs of furanonaphthoquinone (FNQ) from Tecoma ipe Mart had MICs ranging from 1.56 to 25 µg/ml against gram-positive bacteria. FNQ showed significantly lower MICs against methicillin-resistant Staphylococcus aureus than against methicillin-sensitive S. aureus. FNQ inhibited Helicobacter pylori with an MIC of 0.1 µg/ml. Fungi, including pathogenic species, were sensitive to FNQ with MICs similar to those of amphotericin B.

* Corresponding author. Mailing address: Department of Bacteriology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663, Japan. Phone: (81) 798-45-6548. Fax: (81) 798-40-9162. E-mail: kunagata{at}hyo-med.ac.jp.

Antimicrobial Agents and Chemotherapy, March 1998, p. 700-702, Vol. 42, No. 3
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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