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Antimicrobial Agents and Chemotherapy, March 1998, p. 712-714, Vol. 42, No. 3
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Activities of Isoniazid Alone and in Combination with Other Drugs against Mycobacterium avium Infection in Beige Mice

Lanfranco Fattorini, Yan Xiao, Maurizio Mattei, Yongjun Li, Elisabetta Iona, Maria Luisa Ricci, Ove Fredrik Thoresen, Roberta Creti, and Graziella Orefici*

Laboratory of Bacteriology and Medical Mycology, Istituto Superiore di Sanità, 00161 Rome, Italy

Received 28 July 1997/Returned for modification 27 October 1997/Accepted 29 December 1997

Monotherapy with isoniazid or amikacin or clarithromycin or combinations of two of these drugs showed nil to modest therapeutic activity in beige mice infected with Mycobacterium avium. However, the combination of all three, isoniazid-amikacin-clarithromycin, markedly reduced CFUs in both spleens and lungs after 91 days of infection.

* Corresponding author. Mailing address: Laboratory of Bacteriology and Medical Mycology, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Phone: 39 6 49902333. Fax: 39 6 49387112. E-mail: MARELLA{at}NET.ISS.IT.

Antimicrobial Agents and Chemotherapy, March 1998, p. 712-714, Vol. 42, No. 3
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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