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Antimicrobial Agents and Chemotherapy, March 1998, p. 715-716, Vol. 42, No. 3
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

The Antibiotic Micrococcin Is a Potent Inhibitor of Growth and Protein Synthesis in the Malaria Parasite

M. John Rogers,dagger Eric Cundliffe,Dagger and Thomas F. McCutchan*

Growth and Development Section, Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-0425

Received 28 October 1997/Returned for modification 1 December 1997/Accepted 22 December 1997

The antibiotic micrococcin is a potent growth inhibitor of the human malaria parasite Plasmodium falciparum, with a 50% inhibitory concentration of 35 nM. This is comparable to or less than the corresponding levels of commonly used antimalarial drugs. Micrococcin, like thiostrepton, putatively targets protein synthesis in the plastid-like organelle of the parasite.

* Corresponding author. Mailing address: Growth and Development Section, Laboratory of Parasitic Diseases, Building 4, Room B1-28, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425. Phone: (301) 496-6149. Fax: (301) 402-0079. E-mail: mcutchan{at}helix.nih.gov.

dagger Present address: Antimicrobial Group, Du Pont Merck Pharmaceutical Company, Wilmington, DE 19880-0400.

Dagger Present address: Department of Biochemistry, University of Leicester, Leicester LE1 7RH, United Kingdom.

Antimicrobial Agents and Chemotherapy, March 1998, p. 715-716, Vol. 42, No. 3
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Carnio, M. C., Höltzel, A., Rudolf, M., Henle, T., Jung, G., Scherer, S. (2000). The Macrocyclic Peptide Antibiotic Micrococcin P1 Is Secreted by the Food-Borne Bacterium Staphylococcus equorum WS 2733 and Inhibits Listeria monocytogenes on Soft Cheese. Appl. Environ. Microbiol. 66: 2378-2384 [Abstract] [Full Text]  
  • McConkey, G. A. (1999). Targeting the Shikimate Pathway in the Malaria Parasite Plasmodium falciparum. Antimicrob. Agents Chemother. 43: 175-177 [Abstract] [Full Text]  


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