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Antimicrobial Agents and Chemotherapy, April 1998, p. 818-820, Vol. 42, No. 4
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

In Vitro Evaluation of Drug Susceptibilities of Babesia divergens Isolates

Philippe Brasseur,1,* Sophie Lecoublet,1 Nathalie Kapel,2 Loic Favennec,1 and Jean J. Ballet3

Laboratoire de Parasitologie, Centre Hospitalier Universitaire, Hôpital Charles Nicolle, 76031 Rouen,1 Laboratoire de Parasitologie, Faculté de Sciences Pharmaceutiques et Biologiques, 75006 Paris,2 and Laboratoire d'Immunologie et Immunopathologie, Centre Hospitalier Universitaire, Hôpital Clémenceau, 14033 Caen,3 France

Received 18 August 1997/Returned for modification 31 October 1997/Accepted 27 January 1998

The susceptibilities of three bovine and two human Babesia divergens isolates to antimicrobial agents were evaluated in vitro by a tritiated hypoxanthine incorporation assay. The MICs at which 50% of isolates are inhibited (MIC50s) for mefloquine (chlorhydrate), chloroquine (sulfate), quinine (chlorhydrate), clindamycin (phosphate), pentamidine (isethionate), phenamidine (isethionate) plus oxomemazine (chlorhydrate), lincomycin (chlorhydrate monohydrate), and imidocarb (dipropionate) were determined. Except for imidocarb, the MIC50s observed for the different isolates were close. Imidocarb and the combination of phenamidine plus oxomemazine exhibited the highest in vitro activity, while antimalarial agents such as mefloquine, choroquine, and quinine were inactive. Other drugs had intermediate activities. The data support further in vitro evaluation of antimicrobial agents active against B. divergens for the improvement of therapeutic strategies.

* Corresponding author. Mailing address: Laboratoire de Parasitologie, Hôpital Charles Nicolle, 1, rue de Germont, 76031 Rouen, France. Phone: (33) 2 32-88-80-15. Fax: (33) 2 32-88-80-17. E-mail: philippe.Brasseur{at}wanadoo.fr.

Antimicrobial Agents and Chemotherapy, April 1998, p. 818-820, Vol. 42, No. 4
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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