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Antimicrobial Agents and Chemotherapy, April 1998, p. 911-915, Vol. 42, No. 4
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Synthesis and Antibacterial Evaluation of Novel Water-Soluble Organic Peroxides

Wenqiu Liu,1 Xuejun Liu,1 David Knaebel,2 Linda Luck,2 and Yuzhou Li1,*

Department of Chemistry,1 and Department of Biology,2 Clarkson University, Potsdam, New York 13699

Received 25 June 1997/Returned for modification 23 September 1997/Accepted 6 February 1998

A set of new water-soluble organic peroxides has been synthesized and evaluated for in vitro antibacterial activity as part of an effort to develop new antibacterial agents for the treatment of acne vulgaris. The water solubility of these new dialkyl peroxides and peroxyesters was achieved by incorporating either a quaternary ammonium group or a polyethylene glycol moiety. These peroxides are effective against both gram-positive and gram-negative bacteria and have a prolonged activity compared to that of benzoyl peroxide and other peroxide-type antiseptic agents. Among them 4-[[(tert-butylperoxy)carbonyl]benzyl]triethylammonium chloride and [10-(tert-butylperoxy)decyl]trimethylammonium bromide have the broadest antimicrobial spectrums. We have shown that the oxidizing properties of the dioxy group of these compounds are responsible for their antibacterial activities.

* Corresponding author. Mailing address: Department of Chemistry, Clarkson University, Potsdam, NY 13699-5810. Phone: (315) 268-2355. Fax: (315) 268-6610. E-mail: yuzhuoli{at}polaris.clarkson.edu.

Antimicrobial Agents and Chemotherapy, April 1998, p. 911-915, Vol. 42, No. 4
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.




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