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Antimicrobial Agents and Chemotherapy, April 1998, p. 927-929, Vol. 42, No. 4
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Effect of Grapefruit Juice on Clarithromycin Pharmacokinetics

Kit L. Cheng,1 Anne N. Nafziger,2,3 Charles A. Peloquin,4 and Guy W. Amsden1,2,3,*

The Clinical Pharmacology Research Center,2 Department of Pharmacy Services,1 and Department of Medicine,3 Bassett Healthcare, Cooperstown, New York, and The Infectious Disease Pharmacokinetics Laboratory, National Jewish Medical and Research Center, Denver, Colorado4

Received 19 May 1997/Returned for modification 11 November 1997/Accepted 23 December 1997

To investigate whether grapefruit juice inhibits the metabolism of clarithromycin, 12 healthy subjects were given water or grapefruit juice before and after a clarithromycin dose of 500 mg in a randomized crossover study. Administration of grapefruit juice increased the time to peak concentration of both clarithromycin (82 ± 35 versus 148 ± 83 min; P = 0.02) and 14-hydroxyclarithromycin (84 ± 38 min versus 173 ± 85; P = 0.01) but did not affect other pharmacokinetic parameters.

* Corresponding author. Mailing address: The Clinical Pharmacology Research Center, Department of Pharmacy Services, Bassett Healthcare, One Atwell Rd., Cooperstown, N.Y. 13326-1394. Phone: (607) 547-3680. Fax: (607) 547-3629. E-mail: amsden{at}telenet.net.

Antimicrobial Agents and Chemotherapy, April 1998, p. 927-929, Vol. 42, No. 4
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Mertens-Talcott, S. U., Zadezensky, I., De Castro, W. V., Derendorf, H., Butterweck, V. (2006). Grapefruit-drug interactions: can interactions with drugs be avoided?. J Clin Pharmacol 46: 1390-1416 [Abstract] [Full Text]  
  • Garey, K. W., Peloquin, C. A., Godo, P. G., Nafziger, A. N., Amsden, G. W. (1999). Lack of Effect of Zafirlukast on the Pharmacokinetics of Azithromycin, Clarithromycin, and 14-Hydroxyclarithromycin in Healthy Volunteers. Antimicrob. Agents Chemother. 43: 1152-1155 [Abstract] [Full Text]  


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