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Antimicrobial Agents and Chemotherapy, April 1998, p. 934-935, Vol. 42, No. 4
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Efficacy of Sulfamethoxypyridazine in a Murine Model of Pneumocystis carinii Pneumonia

Marilyn S. Bartlett,1 Margaret M. Shaw,1 James W. Smith,1 and Steven R. Meshnick2,*

Department of Pathology and Laboratory Medicine, Indiana University Medical Center, Indianapolis, Indiana,1 and Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan2

Received 17 June 1997/Returned for modification 19 November 1997/Accepted 23 December 1997

Sulfamethoxazole is the component of co-trimoxazole responsible for its efficacy against Pneumocystis carinii pneumonia, but this drug is associated with frequent adverse effects. Sulfamethoxypyridazine is significantly more effective than sulfamethoxazole against a murine model of P. carinii and might be a candidate for testing in infected patients.

* Corresponding author. Mailing address: Department of Epidemiology, University of Michigan School of Public Health, 109 Observatory St., Ann Arbor, MI 48109-2029. Phone: (313) 647-2406. Fax: (313) 764-3192. E-mail: MESHNICK{at}UMICH.EDU.

Antimicrobial Agents and Chemotherapy, April 1998, p. 934-935, Vol. 42, No. 4
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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