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Antimicrobial Agents and Chemotherapy, April 1998, p. 936-938, Vol. 42, No. 4
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Increased Overall Antibiotic Susceptibility in Staphylococcus aureus femAB Null Mutants

Baodong Lingdagger and Brigitte Berger-Bächi*

Institute of Medical Microbiology, University of Zürich, CH8028 Zürich, Switzerland

Received 6 October 1997/Returned for modification 16 December 1997/Accepted 6 February 1998

The staphylococcal pentaglycine side chain of the peptidoglycan is reduced to one glycine in femAB null mutants. This is associated with increased susceptibility to methicillin and to a whole range of unrelated antibiotics as well. Genetic evidence suggests that femAB null mutants are only viable because of a compensatory mutation in an unlinked site.

* Corresponding author. Mailing address: Institute of Medical Microbiology, University of Zürich, Gloriastr. 32, Postfach, CH8028 Zürich, Switzerland. Phone: 41 1 634 26 50. Fax: 41 1 634 49 06. E-mail: bberger{at}immv.unizh.ch.

dagger Present address: Department of Pharmacology, North Sichuan Medical College, Nanchong, Sichuan 637007, China.

Antimicrobial Agents and Chemotherapy, April 1998, p. 936-938, Vol. 42, No. 4
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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  • Rohrer, S., Ehlert, K., Tschierske, M., Labischinski, H., Berger-Bachi, B. (1999). The essential Staphylococcus aureus gene fmhB is involved in the first step of peptidoglycan pentaglycine interpeptide formation. Proc. Natl. Acad. Sci. USA 96: 9351-9356 [Abstract] [Full Text]  
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