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Antimicrobial Agents and Chemotherapy, April 1998, p. 963-964, Vol. 42, No. 4
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Transferable, Plasmid-Mediated VanB-Type Glycopeptide Resistance in Enterococcus faecium

Louis B. Rice,1,2,* Lenore L. Carias,2 Curtis L. Donskey,2 and Susan D. Rudin2

Infectious Diseases Section and Research Service, Cleveland Department of Veterans Affairs Medical Center,1 and the Department of Medicine, Case Western Reserve University School of Medicine,2 Cleveland, Ohio

Received 8 July 1997/Returned for modification 19 November 1997/Accepted 24 January 1998

An approximately 60-kb transferable, vanB-carrying plasmid has been identified in a clinical Enterococcus faecium strain. A similar plasmid has been observed in an unrelated E. faecium strain, suggesting that plasmid transfer of vanB operons occurs in nature and plays a role in the dissemination of VanB-type resistance among strains of E. faecium.

* Corresponding author. Mailing address: Infectious Diseases Section 1110(W), VA Medical Center, 10701 East Blvd., Cleveland, OH 44106. Phone: (216) 791-3800 x4399. Fax: (216) 231-3482. E-mail: lbr{at}po.cwru.edu.

Antimicrobial Agents and Chemotherapy, April 1998, p. 963-964, Vol. 42, No. 4
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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