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Antimicrobial Agents and Chemotherapy, April 1998, p. 984-986, Vol. 42, No. 4
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

In Vitro Activity of Levofloxacin against a Selected Group of Anaerobic Bacteria Isolated from Skin and Soft Tissue Infections

Hannah M. Wexler,1,2,* Eric Molitoris,1 Denise Molitoris,2 and Sydney M. Finegold1,2,3,4

Medical3 and Research2 Services Veterans Administration Medical Center, West Los Angeles, Wadsworth Division, Los Angeles, California 90073, and Departments of Medicine1 and Microbiology and Immunology,4 UCLA School of Medicine, Los Angeles, California 90024

Received 3 July 1997/Returned for modification 13 October 1997/Accepted 5 January 1998

The in vitro activity of levofloxacin was compared to the activities of ofloxacin, ciprofloxacin, ampicillin-sulbactam (2:1), cefoxitin, and metronidazole for a selected group of anaerobes (n = 175) isolated from skin and soft tissue infections by using the National Committee for Clinical Laboratory Standards-approved Wadsworth method. Ampicillin-sulbactam and cefoxitin inhibited 99% of the strains of this select group, levofloxacin and ofloxacin inhibited 73 and 50%, respectively, at 2 µg/ml, and ciprofloxacin inhibited 51% at 1 µg/ml. The geometric mean MIC of levofloxacin was lower than those of ofloxacin and ciprofloxacin for every group except Veillonella.

* Corresponding author. Mailing address: Microbial Diseases Research Laboratory, Bldg. 304, Room E3-224, VA Wadsworth Medical Center 691/151J, Los Angeles, CA 90073. Phone: (310) 268-3404. Fax: (310) 268-4458. E-mail: hwexler{at}ucla.edu.

Antimicrobial Agents and Chemotherapy, April 1998, p. 984-986, Vol. 42, No. 4
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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