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Antimicrobial Agents and Chemotherapy, May 1998, p. 1127-1132, Vol. 42, No. 5
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Activities of HMR 3004 (RU 64004) and HMR 3647 (RU 66647) Compared to Those of Erythromycin, Azithromycin, Clarithromycin, Roxithromycin, and Eight Other Antimicrobial Agents against Unusual Aerobic and Anaerobic Human and Animal Bite Pathogens Isolated from Skin and Soft Tissue Infections in Humans

Ellie J. C. Goldstein,1,2,* Diane M. Citron,1 Sharon Hunt Gerardo,1 Marie Hudspeth,1 and C. Vreni Merriam1

The R. M. Alden Research Laboratory, Santa Monica-University of California, Los Angeles Medical Center, Santa Monica, California 90404,1 and University of California, Los Angeles School of Medicine, Los Angeles, California 900242

Received 7 November 1997/Returned for modification 29 January 1998/Accepted 2 March 1998

The activities of HMR 3004 and HMR 3647 and comparator agents, especially macrolides, were determined by the agar dilution method against 262 aerobic and 120 anaerobic strains isolated from skin and soft tissue infections associated with human and animal bite wounds. HMR 3004 and HMR 3647 were active against almost all aerobic and fastidious facultative isolates (MIC at which 90% of the isolates are inhibited [MIC90], <= 0.5 and 1 µg/ml, respectively) and against all anaerobes [Bacteroides tectum, Porphyromonas macacae (salivosa), Prevotella heparinolytica, Porphyromonas sp., Prevotella sp., and peptostreptococci] at <= 0.25 and <= 0.5 µg/ml, respectively, except Fusobacterium nucleatum (HMR 3004, MIC90 = 16 µg/ml; HMR 3647, MIC90 = 8 µg/ml) and other Fusobacterium species (MIC90, 1 and 2 µg/ml, respectively). In general, HMR 3004 and HMR 3647 were more active than any of the macrolides tested. Azithromycin was more active than clarithromycin against all Pasteurella species, including Pasteurella multocida subsp. multocida, Eikenella corrodens, and Fusobacterium species, while clarithromycin was more active than azithromycin against Corynebacterium species, Weeksella zoohelcum, B. tectum, and P. heparinolytica.

* Corresponding author. Mailing address: 2021 Santa Monica Blvd., Suite 640E, Santa Monica, CA 90404. Phone: (310) 315-1511. Fax: (310) 315-3662. E-mail: EJCGMD{at}aol.com.

Antimicrobial Agents and Chemotherapy, May 1998, p. 1127-1132, Vol. 42, No. 5
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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