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Antimicrobial Agents and Chemotherapy, May 1998, p. 1274-1277, Vol. 42, No. 5
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

In Vitro Activities of Clinafloxacin against Contemporary Clinical Bacterial Isolates from 10 North American Centers

Peter C. Fuchs,* Arthur L. Barry, and Steven D. Brown

The Clinical Microbiology Institute, Wilsonville, Oregon 97070

Received 25 November 1997/Returned for modification 23 January 1998/Accepted 6 March 1998

Clinafloxacin was more active than ciprofloxacin against 4,213 aerobic and facultative anaerobic bacterial isolates from 10 medical centers, as tested by broth microdilution and disk diffusion methods. The percentage of 201 anaerobes susceptible to clinafloxacin by broth microdilution was comparable to cefoxitin. Our data support the proposed disk diffusion interpretive criteria for aerobic bacteria with 5-µg clinafloxacin disks.

* Corresponding author. Mailing address: 9725 S.W. Commerce Circle, Suite A-1, Wilsonville, OR 97070. Phone: (503) 682-3232. Fax: (503) 682-4548 or 682-2065. E-mail: cmi{at}hevanet.com.

Antimicrobial Agents and Chemotherapy, May 1998, p. 1274-1277, Vol. 42, No. 5
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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