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Antimicrobial Agents and Chemotherapy, May 1998, p. 1278-1280, Vol. 42, No. 5
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

A Triazine Dye, Cibacron Blue F3GA, Decreases Oxacillin Resistance Levels in Methicillin-Resistant Staphylococcus aureus

Chiharu Shirai,1,2 Motoyuki Sugai,2,* Hitoshi Komatsuzawa,2 Kouji Ohta,2 Michio Yamakido,1 and Hidekazu Suginaka2

Department of Internal Medicine II, Hiroshima University School of Medicine,1 and Department of Microbiology, Hiroshima University School of Dentistry,2 Hiroshima 734, Japan

Received 20 October 1997/Returned for modification 8 January 1998/Accepted 10 February 1998

Cibacron blue F3GA (CB) was found to reduce the MIC of oxacillin for methicillin-resistant Staphylococcus aureus (MRSA). This effect was not observed with methicillin-susceptible S. aureus. CB alters the resistance level of MRSA through a factor(s) other than mecA-related products, major autolysins, or femAB products. The exact target(s) of CB in causing the effect is unknown.

* Corresponding author. Mailing address: Department of Microbiology, Hiroshima University School of Dentistry, Kasumi 1-2-3, Minami-ku, Hiroshima City, Hiroshima 734-8553, Japan. Phone: 81-82-257-5637. Fax: 81-82-257-5639. E-mail: sugai{at}ipc.hiroshima-u.ac.jp.

Antimicrobial Agents and Chemotherapy, May 1998, p. 1278-1280, Vol. 42, No. 5
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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