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Antimicrobial Agents and Chemotherapy, June 1998, p. 1506-1508, Vol. 42, No. 6
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Characterization of the 6'-N-Aminoglycoside Acetyltransferase Gene aac(6')-Iq from the Integron of a Natural Multiresistance Plasmid

Daniela Centrón1,2,3,* and Paul H. Roy1,2

Département de Biochimie, Faculté des Sciences et de Génie, Université Laval, Sainte-Foy, Québec, Canada G1K 7P41; Centre de Recherche en Infectiologie, Centre de Recherche du CHUL, Sainte-Foy, Québec, Canada G1V 4G22; and Facultad de Medicina de la Universidad de Buenos Aires, (1121) Capital Federal, Argentina3

Received 10 October 1997/Returned for modification 31 December 1997/Accepted 14 March 1998

The nucleotide sequence of a newly identified amikacin resistance gene, aac(6')-Iq (551 bp), is reported. It has 68.4 and 94.4% homology with the aac(6')-Ia gene and the recently described aac(6')-Ip gene, respectively. Analysis of its flanking sequences indicated that it is in the first cassette of a class I integron and has an attC site (59-base element) 108 bp in length.

* Corresponding author. Present address: Dept. Microbiología, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, P-12, (1121) Capital Federal, Argentina. Phone: 54-1-963-6669. Fax: 54-1-962-5404. E-mail: centron{at}ubamib.edu.ar.

Antimicrobial Agents and Chemotherapy, June 1998, p. 1506-1508, Vol. 42, No. 6
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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