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Antimicrobial Agents and Chemotherapy, June 1998, p. 1509-1511, Vol. 42, No. 6
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

In Vitro Activities of the New Ketolide Antibiotics HMR 3004 and HMR 3647 against Streptococcus pneumoniae in Germany

Ralf René Reinert,1,* André Bryskier,2 and Rudolf Lütticken1

National Reference Center for Streptococci, Institute of Medical Microbiology, University Hospital (RWTH) Aachen, Aachen, Germany1 and Hoechst Marion Roussel, Romainville, France2

Received 12 January 1998/Returned for modification 4 March 1998/Accepted 8 April 1998

The comparative in vitro activity of HMR 3004 and HMR 3647, new ketolide antibiotics, was tested by a standard agar dilution technique against 221 pneumococcal strains, including isolates with intermediate levels of resistance to penicillin and erythromycin-resistant isolates. The ketolides were more active than other macrolides and showed excellent activity against erythromycin-resistant strains. All the strains were inhibited by <= 2 µg of HMR 3004/ml or by <= 0.5 µg of HMR 3647/ml.

* Corresponding author. Mailing address: Institute of Medical Microbiology, University Hospital (RWTH) Aachen, National Reference Center for Streptococci, Pauwelsstr. 30, D-52057 Aachen, Germany. Phone: 49 241 8089787. Fax: 49 241 8888 483. E-mail: Reinert{at}RWTH-Aachen.de.

Antimicrobial Agents and Chemotherapy, June 1998, p. 1509-1511, Vol. 42, No. 6
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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