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Antimicrobial Agents and Chemotherapy, July 1998, p. 1578-1580, Vol. 42, No. 7
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Oral Cimetidine Prolongs Clarithromycin Absorption

Guy W. Amsden,1,* Kit L. Cheng,1 Charles A. Peloquin,2 and Anne N. Nafziger1

Clinical Pharmacology Research Center and Departments of Pharmacy and Medicine, Bassett Healthcare, Cooperstown, New York,1 and Infectious Diseases Pharmacokinetics Lab, National Jewish Medical and Research Center, Denver, Colorado2

Received 5 September 1997/Returned for modification 31 January 1998/Accepted 3 April 1998

The present study was conducted to identify any potential interaction between oral cimetidine and clarithromycin. Twelve healthy subjects were administered single doses of clarithromycin alone and with oral cimetidine dosed to steady state. Cimetidine prolonged the absorption of clarithromycin, as evidenced by decreased peak concentrations of both clarithromycin and 14-OH-clarithromycin (14OHC) in serum (46 and 43%, respectively), a delay in the formation of 14OHC (increase of 68%), and increases in both of their half-lives (75 and 82%, respectively), despite no changes in total oral clearance or area under the concentration-time curve for either compound. No mechanism for this interaction has been identified.

* Corresponding author. Mailing address: Clinical Pharmacology Research Center, Department of Pharmacy Services, Bassett Healthcare, One Atwell Rd., Cooperstown, NY 13326. Phone: (607) 547-3680. Fax: (607) 547-3629. E-mail: amsden{at}telenet.net.

Antimicrobial Agents and Chemotherapy, July 1998, p. 1578-1580, Vol. 42, No. 7
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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