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Antimicrobial Agents and Chemotherapy, August 1998, p. 2122-2124, Vol. 42, No. 8
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Topoisomerase Mutations in Trovafloxacin-Resistant Staphylococcus aureus

Joseph E. Fitzgibbon,1,2 Joseph F. John,1,2 Jennifer L. Delucia,2 and Donald T. Dubin1,*

Department of Molecular Genetics and Microbiology1 and Division of Allergy, Immunology and Infectious Diseases, Department of Medicine,2 University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854-5635

Received 28 January 1998/Returned for modification 22 April 1998/Accepted 1 June 1998

A total of 201 Staphylococcus aureus isolates were surveyed for susceptibility to ciprofloxacin and trovafloxacin. Of 66 methicillin-resistant isolates, 89% were ciprofloxacin resistant and 6% were also trovafloxacin resistant. Trovafloxacin-resistant strains had unusual patterns of quinoline resistance mutations in DNA topoisomerase genes, including two mutations in the A subunit (encoded by grlA) of topoisomerase IV.

* Corresponding author. Mailing address: Department of Molecular Genetics and Microbiology, UMDNJ-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854-5635. Phone: (732) 235-4643. Fax: (732) 235-5223. E-mail: dubin{at}umdnj.edu.

Antimicrobial Agents and Chemotherapy, August 1998, p. 2122-2124, Vol. 42, No. 8
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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