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Antimicrobial Agents and Chemotherapy, September 1998, p. 2425-2426, Vol. 42, No. 9
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Prevalence and Characterization of the Mechanisms of Macrolide, Lincosamide, and Streptogramin Resistance in Isolates of Streptococcus pneumoniae

Nicole J. Johnston,1 Joyce C. de Azavedo,1 James D. Kellner,2 and Donald E. Low1,*

Department of Microbiology, Mount Sinai and Princess Margaret Hospitals, and the University of Toronto, Toronto, Ontario,1 and Alberta Children's Hospital and the University of Calgary, Calgary, Alberta,2 Canada

Received 19 September 1997/Returned for modification 16 January 1998/Accepted 16 June 1998

Of a total of 147 erythromycin-resistant Streptococcus pneumoniae isolates, 64 (43.5%) were resistant to erythromycin, clindamycin, and streptogramin B (MLSB phenotype), 57 of which possessed the ermB gene. Eighty-two (55.8%) were resistant to erythromycin alone (M phenotype), 81 of which possessed the mefE gene. One was erythromycin and streptogramin B resistant but susceptible to clindamycin (MS phenotype) and possessed neither the erm gene nor the mefE gene.

* Corresponding author. Mailing address: Department of Microbiology, Mount Sinai Hospital, 600 University Ave., Toronto, Ontario M5G 1X5, Canada. Phone: (416) 586-4435. Fax: (416) 586-8746. E-mail: dlow{at}mtsinai.on.ca.

Antimicrobial Agents and Chemotherapy, September 1998, p. 2425-2426, Vol. 42, No. 9
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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