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Antimicrobial Agents and Chemotherapy, September 1998, p. 2427-2430, Vol. 42, No. 9
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Influence of Human Serum on Pharmacodynamic Properties of an Investigational Glycopeptide, LY333328, and Comparator Agents against Staphylococcus aureus

George G. Zhanel,1,2,3,4,* Iain D. C. Kirkpatrick,4 Daryl J. Hoban,1,3 Amin M. Kabani,1,3 and James A. Karlowsky1,2,3

Department of Medical Microbiology1 and Faculty of Pharmacy,2 University of Manitoba, and Departments of Clinical Microbiology3 and Medicine,4 Health Sciences Centre, Winnipeg, Manitoba, Canada

Received 13 October 1997/Returned for modification 21 February 1998/Accepted 10 June 1998

The MICs and MBCs of 15 antibiotics for two strains of Staphylococcus aureus were determined in Mueller-Hinton broth (MHB) and 90% serum-10% MHB. Subsequent experiments established that highly protein-bound antibiotics (>= 80%), such as LY333328, demonstrated higher MICs and MBCs, less killing over an 8-h interval, and shorter postantibiotic effects in 90% serum-10% MHB than in MHB alone. Albumin was demonstrated to be almost solely responsible for changes in the aforementioned pharmacodynamic parameters of LY333328.

* Corresponding author. Mailing address: Health Sciences Centre, MS673-820 Sherbrook St., Winnipeg, Manitoba R3A 1R9, Canada. Phone: (204) 787-4902. Fax: (204) 787-4699. E-mail: ggzhanel{at}pcs.mb.ca.

Antimicrobial Agents and Chemotherapy, September 1998, p. 2427-2430, Vol. 42, No. 9
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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