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Antimicrobial Agents and Chemotherapy, September 1998, p. 2431-2433, Vol. 42, No. 9
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Superior Efficacy of Liposomal Amphotericin B with Prolonged Circulation in Blood in the Treatment of Severe Candidiasis in Leukopenic Mice

Els W. M. van Etten,* Susan V. Snijders, Wim van Vianen, and Irma A. J. M. Bakker-Woudenberg

Department of Medical Microbiology and Infectious Diseases, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands

Received 26 January 1998/Returned for modification 17 March 1998/Accepted 10 June 1998

In leukopenic mice with severe systemic candidiasis, single-dose treatment (5 mg of amphotericin B [AMB]/kg of body weight) with long-circulating polyethylene glycol-coated AMB liposomes (PEG-AMB-LIP) resulted in zero mortality and a significant reduction in the number of viable Candida albicans in the kidney, whereas 70% mortality was seen in mice treated with five daily doses of AmBisome (5 mg of AMB/kg · day). When the first of five daily doses of AmBisome was combined with a single low dose of Fungizone (0.1 mg of AMB/kg), the efficacy was equal to that of PEG-AMB-LIP.

* Corresponding author. Mailing address: Department of Medical Microbiology and Infectious Diseases, Erasmus University Rotterdam, P. O. Box 1738, 3000 DR Rotterdam, The Netherlands. Phone: 31-10-4088068. Fax: 31-10-4364730. E-mail: vanetten{at}kmic.fgg.eur.nl.

Antimicrobial Agents and Chemotherapy, September 1998, p. 2431-2433, Vol. 42, No. 9
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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