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Antimicrobial Agents and Chemotherapy, September 1998, p. 2434-2436, Vol. 42, No. 9
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Control of Candida albicans Murine Vaginitis by Topical Administration of Polycarbophil-Econazole Complex

E. Ghelardi,1,* A. Tavanti,1 A. Lupetti,1 F. Celandroni,1 E. Boldrini,2 M. Campa,1 and S. Senesi1

Dipartimento di Biomedicina Sperimentale, Infettiva e Pubblica, Università degli Studi di Pisa,1 and Farmigea S.p.A.,2 56127 Pisa, Italy

Received 20 February 1998/Returned for modification 17 March 1998/Accepted 10 June 1998

The complexation of econazole with the mucoadhesive polycarbophil was found to significantly improve the therapeutic benefit of the drug in the topical treatment of experimental vaginal candidiasis in mice, while no difference in the antimycotic activity exerted by econazole and polycarbophil-econazole could be detected in vitro.

* Corresponding author. Mailing address: Dipartimento di Biomedicina Sperimentale, Infettiva e Pubblica, Università degli Studi di Pisa, Via S. Zeno, 35-39, 56127 Pisa, Italy. Phone: 39-50-559423. Fax: 39-50-559462. E-mail: ghelardi{at}biomed.unipi.it.

Antimicrobial Agents and Chemotherapy, September 1998, p. 2434-2436, Vol. 42, No. 9
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Chami, F., Chami, N., Bennis, S., Trouillas, J., Remmal, A. (2004). Evaluation of carvacrol and eugenol as prophylaxis and treatment of vaginal candidiasis in an immunosuppressed rat model. J Antimicrob Chemother 54: 909-914 [Abstract] [Full Text]  


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