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Antimicrobial Agents and Chemotherapy, September 1998, p. 2456-2458, Vol. 42, No. 9
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Antimalarial Activities of Polyhydroxyphenyl and Hydroxamic Acid Derivatives

Kevin P. Holland,1 Howard L. Elford,2 Valerie Bracchi,3 Charles G. Annis,1 Sheldon M. Schuster,1 and Debopam Chakrabarti1,3,*

Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, Florida 326111; Molecules for Health, Inc., Virginia Biotechnology Center, Richmond, Virginia 232192; and Department of Molecular Biology and Microbiology and Center for Diagnostics and Drug Development, University of Central Florida, Orlando, Florida 328163

Received 5 February 1998/Returned for modification 13 May 1998/Accepted 1 July 1998

Several known mammalian ribonucleotide reductase inhibitors featuring a polyhydroxyphenyl and/or hydroxamate moiety as the active group were screened for potency in inhibiting growth of the malaria parasite Plasmodium falciparum. Compounds containing a 2,3- or 3,4-dihydroxyphenyl group as well as benzohydroxamate appear to be the most effective inhibitors of the malaria parasite.

* Corresponding author. Mailing address: Department of Molecular Biology & Microbiology, Bio330, University of Central Florida, Orlando, FL 32816-2360. Phone: (407) 384-2061. Fax: (407) 384-2062. E-mail: dchak{at}pegasus.cc.ucf.edu.

Antimicrobial Agents and Chemotherapy, September 1998, p. 2456-2458, Vol. 42, No. 9
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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