This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vila, J.
Right arrow Articles by Prats, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vila, J.
Right arrow Articles by Prats, G.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, January 1999, p. 161-162, Vol. 43, No. 1
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Increase in Quinolone Resistance in a Haemophilus influenzae Strain Isolated from a Patient with Recurrent Respiratory Infections Treated with Ofloxacin

Jordi Vila,1,* Joaquim Ruiz,1 Ferran Sanchez,2 Ferran Navarro,2 Beatriz Mirelis,2 M. Teresa Jimenez de Anta,1 and Guillem Prats2

Departament de Microbiologia, Institut de Investigació Biomédica August Pi i Sunyer, Hospital Clínic, Facultat de Medicina, Universitat de Barcelona, 08036 Barcelona,1 and Departament de Genètica i Microbiologia, Universitat Autonoma de Barcelona, Hospital de Sant Pau, 08025 Barcelona,2 Spain

Received 26 February 1998/Returned for modification 1 July 1998/Accepted 5 October 1998

The increase in the level of quinolone resistance of Haemophilus influenzae clinical isolates during ofloxacin therapy of a patient with recurrent respiratory infections was investigated. The first isolate (MIC of ciprofloxacin of 2 µg/ml) and the second isolate (MIC of 32 µg/ml) belonged to the same clone, as shown by pulsed-field gel electrophoresis, and the increase in the resistance level was associated with a substitution in Ser-84 to Arg in the ParC protein. These results emphasize the potential risk of development of quinolone-resistant H. influenzae during fluoroquinolone therapy in patients with recurrent respiratory infection.

* Corresponding author. Mailing address: Laboratori de Microbiologia, Hospital Clinic, Villarroel, 170, 08036 Barcelona, Spain. Phone: 34.3.2275522. Fax: 34.3.2275454. E-mail: vila{at}medicina.ub.es.

Antimicrobial Agents and Chemotherapy, January 1999, p. 161-162, Vol. 43, No. 1
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Nakamura, S., Yanagihara, K., Morinaga, Y., Izumikawa, K., Seki, M., Kakeya, H., Yamamoto, Y., Kamihira, S., Kohno, S. (2009). Melting Curve Analysis for Rapid Detection of Topoisomerase Gene Mutations in Haemophilus influenzae. J. Clin. Microbiol. 47: 781-784 [Abstract] [Full Text]  
  • Ho, P. L., Mak, G. C., Tse, C. W. S., Chow, K. H., Cheung, C. H. Y. (2006). Invasive Haemophilus influenzae isolates with decreased levofloxacin susceptibility in Hong Kong. J Antimicrob Chemother 57: 366-366 [Full Text]  
  • Li, X., Mariano, N., Rahal, J. J., Urban, C. M., Drlica, K. (2004). Quinolone-Resistant Haemophilus influenzae: Determination of Mutant Selection Window for Ciprofloxacin, Garenoxacin, Levofloxacin, and Moxifloxacin. Antimicrob. Agents Chemother. 48: 4460-4462 [Abstract] [Full Text]  
  • Li, X., Mariano, N., Rahal, J. J., Urban, C. M., Drlica, K. (2004). Quinolone-Resistant Haemophilus influenzae in a Long-Term-Care Facility: Nucleotide Sequence Characterization of Alterations in the Genes Encoding DNA Gyrase and DNA Topoisomerase IV. Antimicrob. Agents Chemother. 48: 3570-3572 [Abstract] [Full Text]  
  • Perez-Vazquez, M., Roman, F., Aracil, B., Canton, R., Campos, J. (2004). Laboratory Detection of Haemophilus influenzae with Decreased Susceptibility to Nalidixic Acid, Ciprofloxacin, Levofloxacin, and Moxifloxacin Due to gyrA and parC Mutations. J. Clin. Microbiol. 42: 1185-1191 [Abstract] [Full Text]  
  • Morrissey, I., Tillotson, G. (2004). Activity of gemifloxacin against Streptococcus pneumoniae and Haemophilus influenzae. J Antimicrob Chemother 53: 144-148 [Abstract] [Full Text]  
  • Elliott, E., Oosthuizen, D., Johnson, M. M, Piddock, L. J. V. (2003). Fluoroquinolone resistance in Haemophilus influenzae. J Antimicrob Chemother 52: 734-735 [Full Text]  
  • Brenwald, N. P., Andrews, J. M., Jevons, G., Wise, R. (2003). Detection of ciprofloxacin resistance in Haemophilus influenzae using nalidixic acid and BSAC methodology. J Antimicrob Chemother 51: 1311-1312 [Full Text]  
  • Ruiz, J. (2003). Mechanisms of resistance to quinolones: target alterations, decreased accumulation and DNA gyrase protection. J Antimicrob Chemother 51: 1109-1117 [Abstract] [Full Text]  
  • Williams, J. H. Jr (2001). Fluoroquinolones for Respiratory Infections : Too Valuable To Overuse. Chest 120: 1771-1775 [Full Text]  
  • Cardenas, M., Barbe, J., Llagostera, M., Miro, E., Navarro, F., Mirelis, B., Prats, G., Badiola, I. (2001). Quinolone Resistance-Determining Regions of gyrA and parC in Pasteurella multocida Strains with Different Levels of Nalidixic Acid Resistance. Antimicrob. Agents Chemother. 45: 990-991 [Full Text]  
  • Davies, T. A., Kelly, L. M., Hoellman, D. B., Ednie, L. M., Clark, C. L., Bajaksouzian, S., Jacobs, M. R., Appelbaum, P. C. (2000). Activities and Postantibiotic Effects of Gemifloxacin Compared to Those of 11 Other Agents against Haemophilus influenzae and Moraxella catarrhalis. Antimicrob. Agents Chemother. 44: 633-639 [Abstract] [Full Text]  
  • Moss, P. J, Finch, R. G (2000). The next generation: fluoroquinolones in the management of acute lower respiratory infection in adults. Thorax 55: 83-85 [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»