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Antimicrobial Agents and Chemotherapy, January 1999, p. 175-177, Vol. 43, No. 1
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Targeting the Shikimate Pathway in the Malaria Parasite Plasmodium falciparum

Glenn A. McConkey*

Department of Biology, University of Leeds, Leeds LS2 9JT, United Kingdom

Received 12 August 1998/Returned for modification 11 September 1998/Accepted 19 October 1998

The shikimate pathway presents an attractive target for malaria chemotherapy. Three shikimic acid analogs exhibited different effects on Plasmodium falciparum growth. (6R)-6-Fluoro-shikimate and (6S)-6-fluoro-shikimate inhibited growth (50% inhibitory concentrations, 1.5 × 10-5 and 2.7 × 10-4 M, respectively), whereas 2-fluoro-shikimate had no effect. para-Aminobenzoic acid abrogated the inhibition, demonstrating that the shikimate pathway was specifically targeted.

* Corresponding author. Mailing address: Miall Building, Clarendon Way, Department of Biology, University of Leeds, Leeds LS2 9JT, United Kingdom. Phone: 44-113 2332908. Fax: 44-113 2332882. E-mail: g.a.mcconkey{at}leeds.ac.uk.

Antimicrobial Agents and Chemotherapy, January 1999, p. 175-177, Vol. 43, No. 1
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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