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Antimicrobial Agents and Chemotherapy, January 1999, p. 178-180, Vol. 43, No. 1
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Antimicrobial Resistance of 914 Beta-Hemolytic Streptococci Isolated from Pharyngeal Swabs in Spain: Results of a 1-Year (1996-1997) Multicenter Surveillance Study

Fernando Baquero,1 José Angel García-Rodríguez,2 Juan García de Lomas,3 Lorenzo Aguilar,4,* and the Spanish Surveillance Group for Respiratory Pathogensdagger

Microbiology Department, Ramón y Cajal Hospital,1 and Medical Department, SmithKline Beecham Pharmaceuticals,4 Madrid, Microbiology Department, University Hospital, Salamanca,2 and Instituto Valenciano de Microbiología, Valencia,3 Spain

Received 26 May 1998/Returned for modification 22 July 1998/Accepted 5 October 1998

A nationwide susceptibility surveillance study of beta-hemolytic streptococcal isolates from pharyngeal swabs obtained in 11 Spanish hospitals between May 1996 and April 1997 against 12 antibiotics was carried out. Of the isolates 86% (786 of 914 isolates) were group A and 8.4% (77 of 914 isolates) were group C. No resistance was found to beta -lactam antibiotics, but significant differences (P < 0.001) with respect to lack of susceptibility to macrolides were found between groups (27% for group A and 12% for group C) and between seasons (13.2% in summer and 31.7% in winter). Most of these isolates displayed the M phenotype (low-level resistance to erythromycin and susceptibility to clindamycin).

* Corresponding author. Mailing address: Departamento Médico, SmithKline Beecham Pharmaceuticals, Valle de la Fuenfría, 3, 28034 Madrid, Spain. Phone: 34-91-3345275. Fax: 34-91-3345141. E-mail: lorenzo.aguilar-alfaro{at}sb.com.

dagger Composed of M. Gobernado and N. Diosdado, La Fe Hospital, Valencia; E. Bouza and E. Cercenado, Gregorio Marañón Hospital, Madrid; A. Gutierrez and A. García, La Paz Hospital, Madrid; R. Cisterna and A. Morla, Basurto Hospital, Bilbao; E. Perea and L. Martínez, Virgen Macarena Hospital, Seville; M. de la Rosa and A. Martínez-Brocal, Virgen de las Nieves Hospital, Granada; M. Casal and A. Ibarra, Reina Sofía Hospital, Córdoba; I. Trujillano, Clinico Universitario Hospital, Salamanca; R. Gómez-Lus and M. C. Rubio, Clinico Universitario Hospital, Zaragoza; A. C. Gómez-García and F. J. Blanco-Palenciano, Infanta Cristina Hospital, Badajoz; C. García-Riestra and I. Rodríguez, Xeral de Galicia Hospital, Santiago de Compostela; C. Gimeno and D. Navarro, Instituto Valenciano de Microbiología, Valencia; and A. Torrellas, J. J. Granizo, R. Moreno, and R. Dal-Ré, SmithKline Beecham Pharmaceuticals, Madrid, Spain.

Antimicrobial Agents and Chemotherapy, January 1999, p. 178-180, Vol. 43, No. 1
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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