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Antimicrobial Agents and Chemotherapy, October 1999, p. 2542-2546, Vol. 43, No. 10
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Antimicrobial Susceptibility Patterns of Enterococci Causing Infections in Europe

M. A. Schouten, A. Voss, J. A. A. Hoogkamp-Korstanje,* and The European VRE Study Groupdagger

University Hospital St. Radboud, Department of Medical Microbiology, 6500 HB Nijmegen, The Netherlands

Received 2 February 1999/Returned for modification 12 April 1999/Accepted 29 July 1999

In vitro susceptibilities of 4,208 enterococci (83% Enterococcus faecalis isolates, 13.6% Enterococcus faecium isolates, and 3.4% isolates of other species) from patients in 27 European countries towards 16 antibiotics were determined. High-level resistance to gentamicin varied by country (range, 1 to 49%; mean, 22.6% ± 12.3%) and per species (19.7% E. faecalis isolates, 13.6% E. faecium isolates, 3.4% by other species). Vancomycin resistance was detected in 0.06% E. faecalis, 3.8% E. faecium, and 19.1% isolates of other species. All enterococci were susceptible to LY 333328 and everninomicin, and 25% of E. faecalis isolates and 85% of other enterococci were susceptible to quinupristin-dalfopristin. The MIC of moxifloxacin and trovafloxacin for ciprofloxacin-susceptible E. faecalis at which 90% of the isolates were inhibited was 0.25 to 0.5 µg/ml.

* Corresponding author. Mailing address: University Hospital St. Radboud, Department of Medical Microbiology, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Phone: 30-24-3614356. Fax: 30-24-354 0216. E-mail: j.hoogkamp{at}mmb.azn.nl.

dagger Members of the European VRE Study Group are as follows: Austria, C. Jebelean, H. Mittermayer, and M. Rotter; Belgium, M. J. Struelens; Bulgaria, E. E. Keuleyan; Croatia, A. Boras; Czechoslovakia, J. Schindler; Denmark, A. Bremmelgaard, J. Renneberg, N. Frimodt-Moeller, and A. Lester; Finland, O. O. Liimatainen and J. Vuopio-Varkila; France, A. Andremont, C. Muller-Serleys, J. Etienne, and J. Raymond; Germany, L. Bader, J. Heesemann, R. Luetticken, R. R. Reinert, G. Peters, R. Gross, and P. M. Shah; Greece, G. Syrogiannopoulos and O. Vavatsi-Manou; Hungary, A. Marton and E. Nagy; Israel, C. Block and P. Yagupsky; Italy, G. A. Botta, G. Marchiaro, and S. Stefani; Latvia, D. Gardovska and L. Drukalska; Lithuania, V. Usonis; The Netherlands, H. P. Endtz, J. G. M. Koeleman, and J. F. G. M. Meis; Norway, A. Sundsfjord; Poland, M. Basta, P. B. Heczko, and E. Torbicka; Portugal, J. Melo-Cristino; Russia, I. A. Popova; Slovak Republic, V. Krcmercy, Jr.; Slovenia, M. Gubina; Spain, F. Asensi-Botet, C. Riestra, J. R. Cervilla, A. Trilla, and J. Villa; Sweden, L. G. Burman, M. H. Laurel, and M. Rylander; Switzerland, R. Frei; Turkey, G. Kanra; United Kingdom, P. R. Chadwick, E. H. Price, and H. Holzel.

Antimicrobial Agents and Chemotherapy, October 1999, p. 2542-2546, Vol. 43, No. 10
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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