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Antimicrobial Agents and Chemotherapy, October 1999, p. 2547-2549, Vol. 43, No. 10
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Bactericidal Activity and Postantibiotic Effect of Levofloxacin against Anaerobes

Susan L. Pendland,1,2,* Mariela Diaz-Linares,2 Kevin W. Garey,2 Jennifer G. Woodward,3 Seonyoung Ryu,4 and Larry H. Danziger1,2

Microbiology Research Laboratory1 and Department of Pharmacy Practice,2 The University of Illinois at Chicago, Chicago, Illinois 60612; Lutheran General Hospital, Park Ridge, Illinois 600683; and Cedars-Sinai Health Systems, Beverly Hills, California 902114

Received 23 November 1998/Returned for modification 15 April 1999/Accepted 4 August 1999

The bactericidal activity and postantibiotic effect (PAE) of levofloxacin against nine anaerobes were determined. Levofloxacin at concentrations of the MIC and twice the MIC was bactericidal at 24 h to five of nine and nine of nine strains, respectively. The PAE of levofloxacin following a 2-h exposure ranged from 0.06 to 2.88 h.

* Corresponding author. Mailing address: The University of Illinois at Chicago, College of Pharmacy, Department of Pharmacy Practice (M/C 886), 833 South Wood St., Chicago, IL 60612. Phone: (312) 996-8639. Fax: (312) 413-1797. E-mail: pendland{at}uic.edu.

Antimicrobial Agents and Chemotherapy, October 1999, p. 2547-2549, Vol. 43, No. 10
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Stein, G. E., Schooley, S., Tyrrell, K. L., Citron, D. M., Goldstein, E. J. C. (2003). Bactericidal Activities of Methoxyfluoroquinolones Gatifloxacin and Moxifloxacin against Aerobic and Anaerobic Respiratory Pathogens in Serum. Antimicrob. Agents Chemother. 47: 1308-1312 [Abstract] [Full Text]  


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