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Antimicrobial Agents and Chemotherapy, October 1999, p. 2565-2568, Vol. 43, No. 10
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Treatment of Experimental Staphylococcal Endocarditis Due to a Strain with Reduced Susceptibility In Vitro to Vancomycin: Efficacy of Ampicillin-Sulbactam

Mirjana Backo,1,dagger Eliza Gaenger,1 Anna Burkart,1 Yin Li Chai,1 and Arnold S. Bayer1,2,*

Division of Adult Infectious Diseases and St. John's Cardiovascular Research Center, Harbor-UCLA Medical Center, Torrance, California 90509,1 and UCLA School of Medicine, Los Angeles, California 900242

Received 4 February 1999/Returned for modification 9 July 1999/Accepted 4 August 1999

We evaluated several 3-day antimicrobial regimens in the treatment of experimental endocarditis caused by an oxacillin-resistant Staphylococcus aureus strain exhibiting intermediate susceptibility in vitro to vancomycin (VISA). Neither vancomycin alone nor trovafloxacin exhibited in vivo efficacy; addition of amikacin to vancomycin yielded a modest in vivo effect. In contrast, the combination of ampicillin and sulbactam was highly effective in vivo, causing a mean decrease in VISA vegetation densities of >5 log10 CFU/g versus those of untreated controls.

* Corresponding author. Mailing address: Division of Adult Infectious Diseases, Harbor-UCLA Medical Center (Bldg. RB2, Room 225), 1000 West Carson St., Torrance, CA 90509. Phone: (310) 222-6422. Fax: (310) 782-2016. E-mail: Bayer{at}HUMC.EDU.

dagger Present address: School of Medicine, Queen's University, Kingston, Ontario, Canada K7L 2Y1.

Antimicrobial Agents and Chemotherapy, October 1999, p. 2565-2568, Vol. 43, No. 10
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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