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Antimicrobial Agents and Chemotherapy, November 1999, p. 2773-2775, Vol. 43, No. 11
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

In Vitro Susceptibilities of Burkholderia mallei in Comparison to Those of Other Pathogenic Burkholderia spp.

D. J. Kenny, P. Russell,* D. Rogers, S. M. Eley, and R. W. Titball

CBD Porton Down, Salisbury, Wilts SP4 OJQ, United Kingdom

Received 5 November 1998/Returned for modification 15 April 1999/Accepted 18 August 1999

The in vitro antimicrobial susceptibilities of isolates of Burkholderia mallei to 16 antibiotics were assessed and compared with the susceptibilities of Burkholderia pseudomallei and Burkholderia cepacia. The antibiotic susceptibility profile of B. mallei resembled that of B. pseudomallei more closely than that of B. cepacia, which corresponds to their similarities in terms of biochemistry, antigenicity, and pathogenicity. Ceftazidime, imipenem, doxycycline, and ciprofloxacin were active against both B. mallei and B. pseudomallei. Gentamicin was active against B. mallei but not against B. pseudomallei. Antibiotics clinically proven to be effective in the treatment of melioidosis may therefore be effective for treating glanders.

* Corresponding author. Mailing address: CBD Porton Down, Salisbury, Wilts SP4 0JQ, United Kingdom. Phone: 00 44 1980 613438. Fax: 00 44 1980 613097.

Antimicrobial Agents and Chemotherapy, November 1999, p. 2773-2775, Vol. 43, No. 11
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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