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Antimicrobial Agents and Chemotherapy, November 1999, p. 2808-2810, Vol. 43, No. 11
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Distribution of the cfiA Gene among Bacteroides fragilis Strains in Japan and Relatedness of cfiA to Imipenem Resistance

Kikuo Yamazoe,1 Naoki Kato,1,* Haru Kato,2 Kaori Tanaka,1 Yoshihiro Katagiri,3 and Kunitomo Watanabe1

Institute of Anaerobic Bacteriology, Gifu University School of Medicine,1 and Department of Pharmacy, Gifu University Hospital,3 40 Tsukasa-machi, Gifu 500-8705, and Department of Microbiology, School of Medicine, Kanazawa University, Kanazawa 920-8640,2 Japan

Received 15 March 1999/Returned for modification 23 June 1999/Accepted 4 September 1999

The cfiA gene, encoding an imipenem-hydrolyzing metallo-beta -lactamase produced by Bacteroides fragilis, and insertion-like elements were detected by PCR amplification with B. fragilis strains isolated in Japan. The cfiA gene was found in 1.9 and 4.1% of the imipenem-susceptible B. fragilis isolates collected from 1987 to 1988 and from 1992 to 1994, respectively. Insertion-like elements adjacent to the cfiA gene were found in all nine metallo-beta -lactamase-producing imipenem-resistant strains tested but not in nine cfiA-positive strains with no detectable metallo-beta -lactamase activity.

* Corresponding author. Mailing address: Institute of Anaerobic Bacteriology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu 500-8705, Japan. Phone: 81 58-267-2342. Fax: 81 58-265-9001. E-mail: nk19{at}cc.gifu-u.ac.jp.

Antimicrobial Agents and Chemotherapy, November 1999, p. 2808-2810, Vol. 43, No. 11
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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