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Antimicrobial Agents and Chemotherapy, December 1999, p. 3001-3004, Vol. 43, No. 12
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Comparative In Vitro Antimicrobial Activities of the Newly Synthesized Quinolone HSR-903, Sitafloxacin (DU-6859a), Gatifloxacin (AM-1155), and Levofloxacin against Mycobacterium tuberculosis and Mycobacterium avium Complex

Haruaki Tomioka,1,* Katsumasa Sato,1 Tatsuya Akaki,1,2 Hiroko Kajitani,1 Shin Kawahara,3 and Mitsunori Sakatani4

Department of Microbiology and Immunology1 and Department of Dermatology,2 Shimane Medical University, Izumo, Shimane 693-8501, National Sanatorium Minami-Okayama Hospital, Okayama 710-0304,3 and National Sanatorium Kinki-Chuo Hospital, Osaka 591-8555,4 Japan

Received 9 April 1999/Returned for modification 13 August 1999/Accepted 28 September 1999

We compared the in vitro antimycobacterial activity of a new fluoroquinolone, HSR-903, with strong activity against gram-positive cocci with those of levofloxacin (LVFX), sitafloxacin (STFX), and gatifloxacin (GFLX). The MICs of the quinolones for Mycobacterium tuberculosis and Mycobacterium avium complex were in the order STFX approx  GFLX < LVFX less-or-equivalent  HSR-903 and STFX less-or-equivalent  GFLX less-or-equivalent  HSR-903 less-or-equivalent  LVFX, respectively. HSR-903 effectively eliminated intramacrophagial M. tuberculosis, as did LVFX, and exhibited bacteriostatic effects against M. tuberculosis replicating in type II alveolar cells.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Shimane Medical University, Izumo, Shimane 693-8501, Japan. Phone: 81 (853) 20-2146. Fax: 81 (853) 20-2145. E-mail: tomioka{at}shimane-med.ac.jp.

Antimicrobial Agents and Chemotherapy, December 1999, p. 3001-3004, Vol. 43, No. 12
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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