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Antimicrobial Agents and Chemotherapy, December 1999, p. 3030-3032, Vol. 43, No. 12
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Comparative Bacteriostatic and Bactericidal Activities of Cefodizime against Borrelia burgdorferi Sensu Lato

Rossella Murgia,1,* Federico Marchetti,2 and Marina Cinco1

Department of Biomedical Science, University of Trieste, 34127 Trieste,1 and Hoechst Marion Roussel, Milan,2 Italy

Received 1 March 1999/Returned for modification 23 June 1999/Accepted 1 October 1999

The MIC and MSC (minimum spirocheticidal concentration) and killing rate for Borrelia burgdorferi, the etiological agent of Lyme disease, were assessed for cefodizime in comparison with ceftriaxone, minocycline, azithromycin, roxithromycin, and ciprofloxacin. The range of cefodizime MICs was greater than those of azithromycin and roxithromycin but comparable to those of ceftriaxone and minocycline. The MSCs were 1 to 2 dilutions higher than the MICs of all of the tested compounds. The killing curves of cefodizime and ceftriaxone showed parallel courses. In conclusion, cefodizime exerted an activity comparable to that of ceftriaxone against B. burgdorferi.

* Corresponding author. Mailing address: Department of Biomedical Science, University of Trieste, V. Fleming 22, 34127 Trieste, Italy. Phone: 39-040-6767178. Fax: 39-040-567862. E-mail: rmurgia{at}fc.univ.trieste.it.

Antimicrobial Agents and Chemotherapy, December 1999, p. 3030-3032, Vol. 43, No. 12
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Hodzic, E., Feng, S., Holden, K., Freet, K. J., Barthold, S. W. (2008). Persistence of Borrelia burgdorferi following Antibiotic Treatment in Mice. Antimicrob. Agents Chemother. 52: 1728-1736 [Abstract] [Full Text]  


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