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Antimicrobial Agents and Chemotherapy, February 1999, p. 357-359, Vol. 43, No. 2
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Antimicrobial Resistance of 1,113 Streptococcus pneumoniae Isolates from Patients with Respiratory Tract Infections in Spain: Results of a 1-Year (1996-1997) Multicenter Surveillance Study

Fernando Baquero,1 José Angel García-Rodríguez,2 Juan García de Lomas,3 Lorenzo Aguilar,4,* and The Spanish Surveillance Group for Respiratory Pathogensdagger

Microbiology Department, Ramón y Cajal Hospital,1 and Medical Department, SmithKline Beecham Pharmaceuticals,4 Madrid, Microbiology Department, University Hospital, Salamanca,2 and Instituto Valenciano de Microbiología, Valencia,3 Spain

Received 22 May 1998/Returned for modification 7 August 1998/Accepted 12 November 1998

A nationwide susceptibility surveillance of 1,113 Streptococcus pneumoniae isolates was carried out and found the following percentages of resistance: cefuroxime, 46%; penicillin, 37%; macrolides, 33%; aminopenicillins, 24%; cefotaxime, 13%; and ceftriaxone, 8%. A significant (P < 0.05) seasonality pattern for beta -lactam antibiotics was observed. Resistance to macrolides was higher (P < 0.05) in middle-ear samples. Higher percentages of resistance to cefuroxime and macrolides were observed among penicillin-intermediate and -resistant strains, whereas high frequencies of resistance to aminopenicillins and expanded-spectrum cephalosporins were observed only among penicillin-resistant strains.

* Corresponding author. Mailing address: Departamento Médico, SmithKline Beecham Pharmaceuticals, Valle de la Fuenfría, 3, 28034 Madrid, Spain. Phone: 34-91-3345275. Fax: 34-91-3345141. E-mail: lorenzo.aguilar-alfaro{at}sb.com.

dagger The members of the Spanish Surveillance Group for Respiratory Pathogens are T. Jiménez de Anta and F. Marco, Clinic i Provincial Hospital, Barcelona; E. Bouza and E. Cercenado, Gregorio Marañón Hospital, Madrid; R. Gómez-Lus and M. C. Rubio, University Hospital, Zaragoza; M. Gobernado and N. Diosdado, La Fe Hospital, Valencia; I. Trujillano, University Hospital, Salamanca; C. García Riestra and I. Rodríguez, Xeral de Galicia Hospital, Santiago de Compostela; M. de la Rosa and A. Martínez-Brocal, Virgen de las Nieves Hospital, Granada; A. Gutierrez and A. García, La Paz Hospital, Madrid; A. M. Martín Sánchez and F. Cañas, Insular Hospital, Las Palmas; E. Perea and L. Martínez, Virgen Macarena Hospital, Seville; G. Prats and F. Sanchez, Santa Creu i San Pau Hospital, Barcelona; M. Casal and A. Ibarra, Reina Sofia Hospital, Córdoba; R. Cisterna and A. Morla, Basurto Hospital, Bilbao; A. C. Gómez-García and F. J. Blanco-Palenciano, Infanta Cristina Hospital, Badajoz; C. Gimeno and D. Navarro, Instituto Valenciano de Microbiología, Valencia; and A. Torrellas, J. J. Granizo, R. Moreno, and R. Dal-Ré, SmithKline Beecham Pharmaceuticals, Madrid.

Antimicrobial Agents and Chemotherapy, February 1999, p. 357-359, Vol. 43, No. 2
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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